Penicillin-binding protein (PBP)
Penicillin-binding proteins (PBPs) are enzymes that play an important role in the cell membrane and cell wall of bacteria. They are primarily involved in the synthesis of the bacterial cell wall and are essential for maintaining the structure and function of bacteria. PBPs promote cell wall synthesis by catalyzing the crosslinking of peptidoglycans, ensuring that bacteria can withstand external pressures and maintain their morphology. PBPs are expressed in both gram-positive and gram-negative bacteria, but their types and functions may vary between species. Penicillin-binding proteins are important targets for a variety of bacterial infections, such as pneumonia, meningitis, and septicemia[1].
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Penicillin-binding protein (PBP) Related Products (76)
Related Products (76)
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Cephalexin hydrochloride (Standard)
0 ImagesSynonyms: Cefalexin hydrochloride (Standard); Cephacillin hydrochloride (Standard)Cephalexin (hydrochloride) (Standard) is the analytical standard of Cephalexin (hydrochloride). This product is intended for research and analytical applications. Cephalexin (Cefalexin) hydrochloride is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2].
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Cefetamet hydrochloride
0 ImagesCat. No.: HY-A0111BCAS No.: 724438-16-8Synonyms: Ro 15-8074 hydrochloride; Deacetoxycefotaxime hydrochlorideCefetamet (Ro 15-8074) hydrochloride is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet hydrochloride binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet hydrochloride has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet hydrochloride kills and lyses Treponema pallidum. Cefetamet hydrochloride can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
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Cephalexin monohydrate (Standard)
0 ImagesCat. No.: HY-B0200BRCAS No.: 23325-78-2Synonyms: Cefalexin hydrate (Standard); Cephacillin hydrate (Standard)Cephalexin (monohydrate) (Standard) is the analytical standard of Cephalexin (monohydrate). This product is intended for research and analytical applications. Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al.
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FPI-1465
0 ImagesCat. No.: HY-139744CAS No.: 1452458-70-6FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively.
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Cefaclor monohydrate (Standard)
0 ImagesCat. No.: HY-B0198ARCAS No.: 70356-03-5Cefaclor (monohydrate) (Standard) is the analytical standard of Cefaclor (monohydrate). This product is intended for research and analytical applications. Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections.
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Cefetamet-d3
0 ImagesCat. No.: HY-W743473Synonyms: Ro 15-8074-d3; Deacetoxycefotaxime-d3Cefetamet-d3 (Ro 15-8074-d3; Deacetoxycefotaxime-d3) is the deuterium labeled Cefetamet (HY-A0111). Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
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Castalagin
0 ImagesCat. No.: HY-N20707CAS No.: 24312-00-3Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections.
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Antibacterial agent 116
0 ImagesCat. No.: HY-150063CAS No.: 99330-28-6Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain.
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Antibacterial agent 343
0 ImagesCat. No.: HY-183291Antibacterial agent 343 (Compound 47) is an Antibacterial agent. Antibacterial agent 343 binds to the allosteric site of PBP2a to open its active site. Antibacterial agent 343 disrupts bacterial cell membranes, leading to protein leakage. Antibacterial agent 343 interacts with DNA and inhibits replication and transcription. Antibacterial agent 343 induces ROS accumulation. Antibacterial agent 343 exhibits antibacterial activity against MRSA, Staphylococcus aureus, and Enterococcus faecalis. Antibacterial agent 343 can be used for the research of methicillin-resistant Staphylococcus aureus infections.
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Methicillin sodium hydrate (Standard)
0 ImagesCat. No.: HY-121544ARCAS No.: 7246-14-2Methicillin (sodium hydrate) (Standard) is the analytical standard of Methicillin (sodium hydrate). This product is intended for research and analytical applications. Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis.
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FK-041
0 ImagesCat. No.: HY-19234CAS No.: 163009-62-9FK-041 is an orally active cephalosporin antibiotic with high affinity for penicillin-binding proteins (PBPs). FK-041 exhibits broad-spectrum antibacterial activity, exerting potent antibacterial effects against Gram-positive bacteria, most Gram-negative bacteria, anaerobes, and so on. FK-041 also shows good efficacy against some drug-resistant strains such as penicillin-resistant Streptococcus pneumoniae. FK-041 is an antibacterial agent and can be used in the research of infectious diseases.
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Diphenicillin
0 ImagesSynonyms: Ancillin free acid; 2-Biphenylyl penicillin free acid; SKF-12141 free acidDiphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)- resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci.
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Ro 09-1428
0 ImagesCat. No.: HY-117736CAS No.: 134452-47-4Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections.
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Lactivicin
0 ImagesCat. No.: HY-114780CAS No.: 107167-31-7Lactivicin is a non-beta-lactam antibiotic showing beta-lactam action through binding to penicillin-binding protein (PBP). Lactivicin is moderately active against a wide range of Gram-negative bacteria and highly active against Gram-positive bacteria.
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GT-055
0 ImagesCat. No.: HY-139699CAS No.: 2842084-52-8Synonyms: LCB18-055GT-055 (LCB18-055) is a broad-spectrum β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor. GT-055 inactivates β-lactamase, protects GT-1 from hydrolysis, and binds tightly to PBP2, thereby inhibiting cell wall biosynthesis. GT-055 can be used for research on bacterial infections.
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Meropenem sodium
0 ImagesCat. No.: HY-W740053CAS No.: 211238-34-5Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
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VNRX-14079
0 ImagesCat. No.: HY-183080CAS No.: 2872654-37-8VNRX-14079 is an antibacterial agent and PBP2 inhibitor, with an IC50 value of 1.7 μM against wild-type Neisseria gonorrhoeae PBP2. VNRX-14079 forms a covalent bond with Ser310 of PBP2, interacts with multiple residues of PBP2 to stabilize the complex, and induces an inward conformational change of the β3-β4 loop in chimeric PBP2. VNRX-14079 exhibits antibacterial activity against Ceftriaxone (HY-B0712)-resistant Neisseria gonorrhoeae strains. VNRX-14079 can be used in the research of gonorrhea.
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PBP1b-IN-1
0 ImagesCat. No.: HY-181715PBP1b-IN-1 is a penicillin-binding protein inhibitor, with an IC50 of 0.042 μM against PBP1b of Streptococcus pneumoniae and an IC50 of 7.6 μM against PBP3 of Escherichia coli. PBP1b-IN-1 exerts antibacterial activity by targeting penicillin-binding proteins to inhibit bacterial peptidoglycan cross-linking. PBP1b-IN-1 can be used in studies related to bacterial infections.
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DQ 2556
0 ImagesCat. No.: HY-106095CAS No.: 102253-70-3DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins.
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Cefetamet sodium
0 ImagesCat. No.: HY-A0111ACAS No.: 65243-25-6Synonyms: Ro15-8074/001; Deacetoxycefotaxime sodiumCefetamet (Ro 15-8074) sodium is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet sodium binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet sodium has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet sodium kills and lyses Treponema pallidum. Cefetamet sodium can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
